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Lynx names Mary L. Schramke acting chief executive officer
Hayward, California
November 22, 2004

Lynx Therapeutics, Inc. (Nasdaq:LYNX) today announced that Mary L. Schramke Ph.D., 49, has been named acting chief executive officer of the company effective December 15, 2004. Dr. Schramke, who joined Lynx in 2003, succeeds Kevin P. Corcoran, who has resigned as Lynx's president, chief executive officer and director to pursue another business opportunity.

"Mary has integral knowledge of our technology, our products, our markets and our people, and will serve as acting chief executive officer at Lynx while we work toward the completion of our proposed business combination with Solexa," said Craig C. Taylor, Lynx's chairman of the board. "Next-generation DNA sequencing is expected to be based on molecular arrays and both Lynx and Solexa have been advancing toward this target for more than five years. By combining technologies, intellectual property and staffs, we expect to accelerate product development with the goal of releasing our first commercial instrument system in 2005."

"I would like to thank Kevin for his nine years at Lynx, during which he served in a variety of managerial positions and had direct responsibility for our short read DNA sequencing technology," added Mr. Taylor. "We wish him well in his new endeavors."

Commenting on her appointment, Dr. Schramke said, "Along with my colleagues at Lynx, I see an exceptional future for our company through the proposed business combination with Solexa, I firmly believe this proposed business combination is in the best interest of our company, our customers, our employees and our stockholders. I am delighted to participate as acting chief executive officer and I am committed to getting this transaction completed."

Dr. Schramke joined Lynx in 2003 as senior director of business development and was subsequently promoted to vice president of product development. Previously she was a biotechnology business development consultant at InterPro Services, Inc. Dr. Schramke also served for three years at the gene discovery firm, Hyseq Pharmaceuticals, Inc., most recently as vice president of business development. She has held a variety of managerial positions at Cellomics, Inc., CLONTECH Laboratories and Bio-Rad Laboratories. Dr. Schramke holds a Ph.D. in microbiology from Louisiana State University, Baton Rouge, and completed her post-doctoral training in genetics at the University of Missouri-Columbia. Dr. Schramke also holds an MBA from John F. Kennedy University.

On October 29, 2004, Lynx filed a Registration Statement on Form S-4 regarding the proposed transaction with Solexa and other matters with the Securities and Exchange Commission (SEC), which is available at the SEC's Web site at www.sec.gov. The transaction, which is subject to approval by the Lynx stockholders and acceptance by the Solexa shareholders, is expected to close in the first quarter of 2005.

Lynx is a leader in the development and application of novel genomic analysis solutions. Lynx's short read sequencing instruments analyze millions of DNA molecules in parallel enabling genome structure characterization at an unprecedented level of resolution. As applied to gene expression analysis, short read sequencing provides comprehensive and quantitative digital information important to modern systems biology research in the pharmaceutical, biotechnology and agricultural industries.

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