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NEWS

Paradigm Genetics exceeds fourth consecutive technical milestone In commercial partnership with Monsanto

Research Triangle Park, North Carolina
March 7,  2001

Paradigm Genetics, Inc. (Nasdaq: PDGM), a functional genomics company, today announced it has exceeded the fourth consecutive milestone in its commercial partnership with Monsanto Company (NYSE: MON). Paradigm will receive an undisclosed accelerated milestone payment for this accomplishment. 

Under the terms of the commercial partnership, Paradigm is using its industrial-scale GeneFunction Factory(TM) to discover the function of genes selected by Monsanto for use in its product development program. Paradigm will share in any product revenues generated through this collaboration in the form of royalties. The collaboration agreement was expanded in May 2000 to include Renessen LLC, a joint venture between Monsanto and Cargill Inc., which develops quality traits and customized products that enhance the functionality of grains, oilseeds, and other crops.

"Paradigm has put in place an impressive high-throughput system," said Chris Burnley, Vice President for Genomics Strategy & Alliances at Monsanto. "They continue to be a great collaborator and a critical part of our integrated discovery platform." "To date, Paradigm has routinely outperformed on very ambitious technical milestones. This success is directly attributable to the commitment given to this program by the Paradigm and Monsanto team members," said John A. Ryals, Ph.D., CEO and President of Paradigm Genetics. "The efficiencies of our GeneFunction Factory(TM) continue to improve. We are working to enhance them further when our new, higher-capacity facility comes on line next month. Our success increases the likelihood that commercial partners such as Monsanto will be successful in new product development."

Paradigm brings to the collaboration its expertise in gene function analysis and bioinformatics. Paradigm's high-throughput analysis methodology is comprised of a series of proprietary analytical processes combined with a computerized knowledge base of plant and fungal gene function information.

Paradigm Genetics is industrializing the process of gene function discovery for four major sectors of the global economy: human health, nutrition, crop production and industrial products. The company has designed the GeneFunction Factory(TM) - an integrated, rapid, industrial-scale
laboratory through which it discovers gene function. Paradigm and its strategic partners intend to develop novel products using information developed with the GeneFunction Factory(TM). Paradigm's GeneFunction Factory(TM) is based on a state of the art phenomics platform integrated with metabolic profiling and gene expression profiling technologies. The backbone
of the GeneFunction Factory(TM) is the company's proprietary FunctionFinder(TM) bioinformatics system, used to collect, store, analyze and retrieve information. For more information visit www.paragen.com

GeneFunction Factory(TM) and FunctionFinder(TM) are U.S. trademarks of Paradigm Genetics, Inc.

Company news release
N3358

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