Henderson, Nevada
January 25, 1999AgriBioTech,
Inc. announced today that it has purchased all the outstanding shares of
HybriGene, LLC, a biotechnology company with an extensive patent estate involving site
specific
recombination technology originally developed at Purdue University.
In addition, as part of the transaction, ABT acquired exclusive, worldwide rights to use
the technology in all crops, species, applications and geographies. Included in the
technology acquired are four promoters, DNA sequences used to ``turn on'' genes by
providing a gene with instructions regarding when in development and where in the plant
they will be active.
One promoter results in constitutive gene expression (activity in most tissues) at a very
high level
(believed equal to or better than the CAMV 35S promoter, which is the current industry
standard).
The biotechnology that ABT has acquired through the purchase of HybriGene and the
associated
exclusive worldwide licenses for all applications has at minimum two broad applications.
It provides a method for developing male sterility in plants (male sterility means not
capable of reproduction because no viable pollen is produced); these male sterile plants
can be used to create hybrids of any plant species.
One important feature of the technology is that when newly engineered traits are placed in
male sterile plants there would be no transgenic pollen, which eliminates the major means
of possible migration of transgenic traits from grass to weed species, for instance. It
should speed the practical application of transgenic traits in forage and turfgrass
species.
The second broad application of the technology provides an alternative way of regulating
gene activity. It allows for the control of expression of new transgenes in plants -- they
can be either turned on or off, and this is even possible in any generation of the plant.
This technology has potential for the production of specialty chemicals in plants such as
pharmaceuticals, industrial compounds such as plastics, industrial enzymes, etc. Compounds
that are even toxic to the plant can be produced because the gene can be kept silent
during the ramp-up of seed multiplication and then turned on only during the last
generation. The plants or seeds are then harvested for extraction of the new compound.
As part of this agreement, ABT has formed a broad research alliance with Pure Seed Testing
for
development of transgenic bentgrass, bluegrass and other turf species using both parties
germplasm. The exclusive stable of patents when developed will provide male sterile
plants, which will carry genes for herbicide resistance, disease resistance and other
valuable traits to protect plants. Each party will have the ability to eventually market
proprietary varieties that have been transformed with new traits.
``This patent estate and related technology gives ABT important new tools in our efforts
to build a
leading plant biotechnology program,'' said Dr. Tom Rice, ABT vice president and director
of
Research.
``The new tools we have acquired and the research alliance with Pure Seed Testing
increases our
ability to develop new, value-added products for our strategic sector (turfgrass and
forage seeds) as well as work with other plant genetics and seed companies to help them
realize their goals.''
ABT management believes that the new technology brought to the company by this agreement
adds significantly to its internal biotechnology capabilities, and complements its other
biotechnology and R&D agreements. Johnny Thomas, Ph.D., ABT Chairman and CEO said ``We
are committed to leading in the introduction of improved, value-added products in the
forage and turfgrass seed industry, and this agreement is just one example of that.''
In the past seven months, ABT has announced agreements and/or letters of intent to
strengthen its R&D and biotechnology position with: Garst Seed Co. (part of the
Advanta seed group) for a research license, and commercialization license at ABT's option,
to ``whiskers'' transformation technology; a license and marketing agreement regarding Bt
with Mycogen Corp., now a wholly owned subsidiary of The Dow Chemical Co. (DOW); Kimeragen
for a license to chimerplasty; Global Agro, Inc. for a biotechnology license and access to
genes and the purchase of an equity position in the company; the Noble Foundation for
rights to genes that potentially may improve digestibility of alfalfa; and FFR Cooperative
for access to leading forage and forage grass germplasm and an R&D alliance.
In addition, the company recently announced the opening of an ABT molecular biology and
biotechnology laboratory at the University of Rhode Island, and a marketing agreement
regarding
herbicide resistant alfalfa. ABT is currently also in discussions with other biotechnology
asset owners and potential partners.
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