3-Dimensional Pharmaceuticals, Inc. (3DP) and Hoechst Schering AgrEvo GmbH today announced a strategic collaboration in which 3DP's DirectedDiversity® technology will be used to discover and refine innovative new agrochemicals.

3DP will provide libraries of diverse compounds to AgrEvo, and will make available its
DirectedDiversity® Technology to optimize active compounds identified from screening the compound libraries. AgrEvo will receive the exclusive right to commercialize agricultural products discovered during the course of the collaboration. 3DP will retain rights for non-agrochemical uses of compounds developed through the collaboration.

"3DP's technology brings together a unique blend of powerful computational tools, combinatorial
chemistry and high-throughput screening techniques,'' said Dr. Friedrich Wengenmayer, Head of
Research, Agrochemicals, AgrEvo. "We believe it has the potential to make a significant contribution to our research and development efforts.''

F. Raymond Salemme, Ph.D., 3DP President and Chief Scientific Officer, noted that 3DP scientists are looking forward to working with their colleagues at AgrEvo. "We are confident 3DP's technology will enhance AgrEvo's discovery efforts and will help speed the time to market for new agrochemical products. This is a multi-million dollar agreement in which 3DP will receive payment for delivery of compounds, research and development funding, license fees and royalties on resulting products. Equally important is the continued market validation of our proprietary technology brought by this collaboration with one of the world's leading companies in agricultural biotechnology and chemistry.''

DirectedDiversity® is a patented, computer-aided, iterative process for generating chemical
compounds with a prescribed set of physical, chemical and/or biological properties. A key feature of the technology is that DirectedDiversity® Accessible Compound Libraries are initially generated and indexed using a comprehensive set of more than 200 molecular descriptors to allow rapid retrieval of compounds with user-selectable ranges of structural and chemical properties. 3DP to date has developed Accessible Libraries totaling over 1.5 billion compounds, virtually any of which can be synthesized through automated chemistry. To prime its drug and chemical discovery process, 3DP has synthesized DirectedDiversity® Probe Libraries that include diverse selections of over 150,000 compounds from the Accessible Libraries.

AgrEvo is a global leader in biotechnology, seeds, crop protection and environmental health. The
company markets globally a range of products for enhancing crop production, together with
applications for urban pest control. AgrEvo operates in more than 70 countries with approximately
8,600 employees.

3-Dimensional Pharmaceuticals, Inc. is a leading innovator in drug discovery. The company has
developed a proprietary technology platform known as DiscoverWorks(TM), which uniquely integrates structure-based drug design, combinatorial chemistry and high-throughput screening.
DiscoverWorks(TM) reduces discovery costs, increases the rate of success and enhances the ultimate commercial value of a drug development pipeline. 3DP is using its proprietary technology both in collaboration with other companies and in its own research programs, which currently target orally active small-molecule pharmaceuticals to treat cardiovascular disease and cancer.

Company news release
N2184