Sangamo BioSciences, Inc. (Nasdaq: SGMO) today reported financial results for the fourth quarter ended December 31, 2006. Revenues for the fourth quarter of 2006 were $2.2 million as compared to fourth quarter 2005 revenues of $1.4 million. The principal components of fourth quarter 2006 revenues were from Sangamo's research agreement with Dow AgroSciences (DAS), research grants and partnerships in enabling technologies and human therapeutics.

The consolidated net loss was $8.9 million, or $0.26 per share, as compared to a net loss of $2.7 million, or $0.10 per share, in the same period in 2005. As of December 31, 2006, the company had cash, cash equivalents, and investments of $54.0 million.

Total fourth quarter 2006 operating expenses were $12.0 million as compared to $4.3 million in the prior year period. Research and development expenses were $10.1 million for the three months ended December 31, 2006 and $2.7 million for the same period in 2005. Research and development expenses in the fourth quarter of 2006 were higher than in the same period of 2005 due to Sangamo's acquisition of the Edwards Lifesciences (Edwards) ZFP Therapeutic angiogenesis programs, increased expenses relating to our clinical trials and employee stock-based compensation. In December 2006, Sangamo purchased Edwards' ZFP Therapeutics programs in exchange for one million shares of Sangamo common stock and certain royalties, a transaction valued at $5.8 million. General and administrative expenses were $1.9 million for the fourth quarter of 2006 as compared to $1.6 for the same period in 2005. Total expenses also included a non-cash charge of $493,000 during the fourth quarter ended December 31, 2006 for employee stock-based compensation.

Net interest income for the fourth quarter of 2006 was $698,000 as compared to $293,000 in the comparable period of 2005.

Twelve Month Results

For the year ended December 31, 2006 revenues were $7.9 million as compared to $2.5 million in 2005. The net loss for the year ending December 31, 2006 was $17.9 million, or $0.55 per share, compared to $13.3 million, or $0.51 per share, for the year ended December 31, 2005. Total operating expenses for the years ended December 31, 2006 and 2005 were $28.6 million and $16.2 million, respectively. Total expenses for the year ended 2006 included the $5.8 million expense associated with the acquisition of the Edwards ZFP Therapeutic programs as well as a non-cash charge of $2.0 million for employee stock-based compensation. As of January 1, 2006 the Company adopted Statement of Financial Accounting Standards No. 123R and is reporting employee stock- based compensation expense in its GAAP results.

As of December 31, 2006, the company had cash, cash equivalents, and investments of $54.0 million, compared with $47.2 million at December 31, 2005. Total shares outstanding at December 31, 2006 were 35.0 million as compared to 30.6 million at December 31, 2005.

Recent Highlights

• Initiation of Phase 2 clinical trial of SB-509 for diabetic neuropathy.
  In November 2006, Sangamo announced that it had initiated a multi-center, double-blind, placebo-controlled, Phase 2 clinical trial of SB-509 for diabetic neuropathy (DN) designed to evaluate the clinical safety and clinical effects of repeat administration of SB-509 in diabetics with mild to moderate diabetic peripheral sensory motor neuropathy in the legs. The Juvenile Diabetes Research Foundation (JDRF) is providing up to $3 million of financial support for the study payable on achievement of certain milestones. SB-509 is an injectable formulation of plasmid DNA that encodes a zinc finger DNA-binding protein transcription factor (ZFP TF(TM)), designed to upregulate the vascular endothelial growth factor A (VEGF-A) gene.

• Acquisition of Edwards' ZFP Therapeutic angiogenesis program.
  In early December, Edwards and Sangamo announced Sangamo's acquisition of the Edwards ZFP Therapeutic angiogenesis program that was completed on December 22, 2006. Edwards transferred the assets of these programs to Sangamo in exchange for 1 million shares of Sangamo common stock and royalties on certain Sangamo products commercialized in the future based upon ZFP activation of the VEGF gene. In addition to acquiring two clinical stage programs in peripheral artery disease (PAD), a pre-clinical program in ischemic heart disease (IHD) and ten grams of clinical grade drug, the agreement enables coordinated implementation of Sangamo's future clinical trials and corporate partnering opportunities. Future clinical development plans for these assets will be discussed on today's conference call.

• Achievement of first milestones in agreement with Dow AgroSciences (DAS).
  In November 2006, DAS and Sangamo announced the successful completion of multiple research milestones as part of their Research and Commercial License Agreement initiated October 2005.

• Michael J. Fox Foundation for Parkinson's Research (MJFF) awards Sangamo funds to develop novel ZFP Therapeutic for the treatment of Parkinson's disease (PD). 
  The $950,000 grant, which will be paid over a period of two years will be used to develop ZFP TFs to activate the expression of glial cell line-derived neurotrophic factor (GDNF), a potent neurotrophic factor that has shown promise in preclinical testing to slow or stop the progression of Parkinson's disease. Use of a ZFP TF to activate the GDNF gene in the brain -- as compared to addition of a GDNF cDNA or the recombinant protein -- may allow the delivery of a more physiologically relevant dose of the growth factor. This may be of particular significance when targeting potent natural growth factors such as GDNF, where sufficient but not super- physiological levels of the therapeutic protein may be required to achieve potency with safety.

• Sangamo and City of Hope (COH) announce license agreement and research collaboration to develop a treatment for brain cancer.
  Sangamo entered into an exclusive, worldwide license agreement with COH for intellectual property related to a chimeric immunoreceptor useful in treating human cancers. Sangamo and COH also entered into a research collaboration to develop a novel cell therapy combining the licensed technology with Sangamo's proprietary zinc finger DNA-binding protein nuclease (ZFN(TM)) technology for treatment of glioblastoma multiforme (GM), a progressive and usually fatal brain cancer. Sangamo expects to file an IND for this program with the U.S. FDA in the second half of 2007.

• Sangamo hosts Investor and Analyst Briefing.
  On December 6, 2006, Sangamo provided an update on its achievements in 2006, its therapeutic
  programs, progress in its collaboration with Dow AgroSciences and its objectives for 2007 during its annual Investor and Analyst Briefing held in New York. The event was webcast and the replay is available on
  Sangamo's website at http://phx.corporate-ir.net/phoenix.zhtml?c=120938&p=irol-IRHome

Sangamo BioSciences, Inc. is focused on the research and development of novel DNA-binding proteins for therapeutic gene regulation and modification. The most advanced ZFP Therapeutic(TM) development program is currently in a Phase 2 clinical trial for evaluation of safety in patients with diabetic neuropathy. Phase 1 clinical trials are ongoing to evaluate a ZFP Therapeutic for peripheral artery disease. Other therapeutic development programs are focused on ischemic heart disease, neuropathic pain, cancer and infectious and monogenic diseases. Sangamo's core competencies enable the engineering of a class of DNA-binding proteins known as zinc finger DNA-binding proteins (ZFPs). By engineering ZFPs that recognize a specific DNA sequence Sangamo has created ZFP transcription factors (ZFP TF(TM)) that can control gene expression and, consequently, cell function. Sangamo is also developing sequence-specific ZFP Nucleases (ZFN(TM)) for therapeutic gene modification as a treatment for a variety of monogenic diseases, such as X-linked SCID and hemophilia, and for infectious diseases, such as HIV. Sangamo has established several Enabling Technology Agreements with companies to apply its ZFP Technology to enhance the production of protein pharmaceuticals. For more information about Sangamo, visit the company's web site at http://www.sangamo.com/.