Chromos' spin-off Agrisoma Biosciences completes private financing

Burnaby, British Columbia
December 10, 2002

Chromos Molecular Systems Inc. ("Chromos"; TSX: CHR) and its subsidiary Agrisoma Biosciences Inc. ("Agrisoma") announced today that Agrisoma has closed a private financing. Proceeds will be used to fund future operations and advance Agrisoma's research and development programs. Agrisoma is an early stage biotechnology company focused on developing and commercializing its chromosome-based gene transfer technology to enable the discovery and development of high value traits in crops and enable the production of proteins in plant-based systems.

"The success of this financing is further validation of the value and the diverse applications of our platform technology," said Alistair Duncan, President and CEO of Chromos. "Despite the difficult financing climate, we have received the endorsement and strong support of the investment community and the ag-bio sector for Agrisoma and its prospects. Agrisoma can move ahead with its own resources to advance the work already initiated in plant-based systems, while Chromos can dedicate its resources to progressing its mammalian platform for the manufacture of therapeutic proteins and cell-mediated gene therapies."

The investment syndicate for this financing included the Business Development Bank of Canada and an MDS Capital Group company, MedInnova Partners Inc. The financial terms of the deal were not disclosed.

Chromos also announced today that Agrisoma has secured additional non- dilutive funding from NRC's Industrial Research Assistance Program (IRAP), to further lever its research capital.

"I am very pleased by the successful completion of this financing for Agrisoma. The quality of the investors with their strong connection to the biotech industry are major components for the future growth of the company, putting Agrisoma in an enviable position to continue to raise independent capital," said Darrell Elliott, Chairman of Chromos' Board of Directors. With Chromos maintaining an equity position in Agrisoma, this arrangement will enable our shareholders to benefit from the success of the spinout and realize shareholder value much more rapidly than if we had tried to do it all in Chromos itself."

The funds raised will be used to advance the development of Agrisoma's chromosome-based gene transfer technology in plant-based systems. Competitive features of Agrisoma's technology include its large and multiple gene carrying capacity, its ability to maintain the long term and stable expression of theses genes, and its ability to selectively and predictably control protein expression. A major limitation of conventional gene transfer technologies is their limited capacity to transfer large amounts of DNA, an important feature to enable crops to express multiple traits or large complex genes. Agrisoma's technology overcomes this barrier.

Agrisoma's business objective is to deploy its technology with multiple partners in 3 large and growing markets focused on (1) crop variety development (2) screening and discovery tools for plant genomics and (3) production of therapeutic and industrial proteins in plant systems.

Chromos Molecular Systems Inc. is a public, Canadian biotechnology company leading the development of innovative therapies using a proprietary gene delivery and expression system for the production of therapeutic proteins and cell-mediated gene therapies.

Chromos is achieving this objective with a unique mammalian chromosome technology platform from which multiple product candidates can be developed. Chromos' technology, referred to as The ACE System, is a unique and powerful vehicle for carrying genes into cells. It offers competitive advantages over current systems in that it permits the rapid and efficient insertion of selected genes, allows for the long term and stable expression of large, single or multiple proteins, and provides a means to selectively and predictably control protein expression.

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