April 9, 2003
Cellectis SA, a spin-off
from the Pasteur Institute, specialized in rational genome
engineering, today announced that the company has entered into
an agreement with Limagrain
Group, 4th
seed business company in the world.
The agreement includes an option for a non-exclusive worldwide
commercial license for the use of the MRS technology, owned by
Cellectis. This technology is based on the use of the
Meganuclease I-SceI, a
very rare and highly specific restriction endonuclease, for the
induction of homologous recombination and site directed
insertion or deletion of gene(s) of interest.
The contract concerns the major crops, field
crops as well as vegetables. Through this agreement, Biogemma,
common subsidiary of Limagrain and other seed and agricultural
and financial business organizations will be entitled to use the
technology. "We wish to apply Cellectis’ technology to develop
even more accurate plant breeding tools" insists Michel Debrand,
CEO of Biogemma.
"We believe that the applications of our
Meganuclease Recombination System will be fundamental in
Agriculture, where precise and rational genome engineering are
the necessary trends", says Dr. André Choulika, President & CEO
of Cellectis, "especially as our technology offers specific
advantages over other site-specific systems ". And concludes "We
are very pleased with this new deal in the Plant Biotech domain
with the European leader of the seed industry".
Limagrain is an independent co-operative group,
owned by Farmers, and employing 5,200 people from over 40
different nationalities. Limagrain, with a turnover of 1 billion
euro, is the 4th seed business company, with a European lead in
Field crops and vegetables. 12% of its turnover is dedicated to
Research. Limagrain invests heavily in plant biotechnology
through an active partnerships policy.
Biogemma SAS is a European company specialized
in plant biotechnology research, created and financed by
agricultural and financial business companies. Biogemma regroups
specialists of plant breeding and organizations sustaining
downstream agro-industrial activities, the co-operative groups
Limagrain, Euralis and RAGT, and the financial corporations
Sofiproteol and Unigrains. Through 4 main research centers in
France and Europe, Biogemma employs more than 100 people.
Biogemma has developed partnerships with the public research
through the genomic research programme Genoplante from the
beginning in 1999.
Cellectis SA was founded in 1999, as a spin-off
from the Pasteur Institute. It is the first company to apply the
Meganuclease Recombination System approach to in vivo genome
engineering. Cellectis is focused on the research and
development of novel Meganucleases for genome intervention and
provides tools for in vivo site directed recombination. The
company is developing Meganucleases that can target a unique DNA
break in vivo, as a fundamentally enabling technology for
commercial applications in human therapeutics, pharmaceutical
discovery, agriculture and industrial biotechnology. Cellectis’
team today consists of 36 people including 14 PhDs and the total
invested capital since the company’s inception is approximately
EUR 20 million.
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