Vacaville, California
December 19, 2002

Large Scale Biology Corporation (Nasdaq:LSBC) will undertake new funded research for Growers Research Group LLC (GRG) under a new contract announced today. LSBC and GRG announced a previous deal related to lysozyme material on June 27, 2002. LSBC and GRG have been collaborative partners under other contracts for more than two years, and now expect to develop novel antimicrobial products for plant protection purposes through the application of LSBC's proprietary GENEWARE(R) technology. Financial details were not disclosed.

Richard Smith, Managing member of GRG, called the contract "an important further step in Growers Research Group's productive partnership with LSBC and its unique team of scientists."

"GRG has been a valued collaboration partner for many years. This fifth deal with them reflects the strength of our partnership and validation of the value we have delivered for an important client," said LSBC President John D. Fowler. "The commercial advantages of our GENEWARE system continue to grow."

Growers Research Group, LLC is a private company whose members are a consortium of California agribusiness concerns, organized for the purpose of conducting research for the protection, promotion and development of agriculture and for the commercial application of the results of that research.

Large Scale Biology Corporation (Nasdaq:LSBC) uses its functional genomics, proteomics, and biomanufacturing technologies to develop and manufacture personalized drugs, vaccines and diagnostics for rapid identification and effective treatment of disease. Corporate offices and the Research and Pharmaceutical Development divisions are headquartered in Vacaville, California; the Proteomics Division is located in Germantown, Maryland; and the Biomanufacturing Division is located in Owensboro, Kentucky.

LSBC(TM) is a trademark of Large Scale Biology Corporation. GENEWARE(R) is a registered trademark of Large Scale Biology Corporation.